About the Respiratory Pathogen Panel (RPP)

Lower Respiratory Infections (LRI) are in the top 10 causes of death among children in the US; 3%-14% of LRI hospitalizations require admission to an ICU. Upper Respiratory Infections (URI) are the most frequent infection in children in the US. Misdiagnosed and mistreated LRIs and URIs foster contagion, and can lead to hospitalizations and even death. Excelsior Diagnostic’s comprehensive PCR-based RPP screens for 20 total targets in a single test, covering most commonly circulated viruses, and detects mixed or co-infections. Rapid results and accurate testing allow healthcare providers to optimally identify and treat causative pathogens and contain the spread of the disease.

  • 5.3 million children with LRIs annually
  • 11 million adults with LRIs annually
  • 50% symptomatic illnesses caused by URIs
  • 3-5 million illnesses caused by flu annually, with 100,000-200,000 hospitalizations
  • 250,000 – 500,000 flu related deaths each year
  • Healthcare cost of flu epidemics in the northern hemisphere are at $12 million each year

How is the test done?

A nasal swab is easily obtained using the convenient ESwab™ Liquid Amies Collection and Transport System, placed in a pre-paid FedEx or UPS clinical pack and overnighted to Excelsior Diagnostics. The specimen is processed by PCR molecular technology and resulted in four hours. When the test is positive, the identified bacteria is automatically submitted for Antibiotic Resistance (ABR) Screening, to immediately identify the most effective antibiotic treatment.

How is that better than the standard legacy method?

Excelsior’s RPP is the most comprehensive screening panel available today, screening for 20 targets in a single test. Same day results of both the culture and the Antibiotic Resistance (ABR) Panel detect mixed or co-infections, and can effectively filter novel strains through sub-typing, mitigating the spread of viruses. Accurate detection enables health care providers to treat infections more quickly and precisely than any other screening method, resulting in better treatment outcomes – especially in children, and elderly or immunocompromised patients.

2 BACTERIAL TARGETS

Chlamydophila Pneuomoniae

Mycoplasma Pneumoniae

18 VIRAL TARGETS
Influenza A / Influenza A H1 / Influenza A H3 / Influenza B / Rhinovirus/ Enterovirus / Adenovirus / Parainfluenza Virus 1 / Parainfluenza Virus 2 / Parainfluenza Virus 3 / Parainfluenza Virus 4  / Respiratory Syncycial Virus A / Respiratory Syncytial Virus B / Coronavirus HKU1 / Coronavirus NL63 / Coronavirus OC43 / Coronavirus 229E / Human Metapneumovirus / Human Bocavirus

View the Complete Antibiotic Resistance Panel (ABR)

Antibiotic – Gene
  • Methicillin – mecA
  • Vancomycin – VanA1
  • Vancomycin – VanA2
  • Vancomycin – VanB
  • Quinolone and fluoroquinolone resistance – QnrA
  • Quinolone and fluoroquinolone resistance – QnrB
  • Macrolide resistance – ErmA
  • Macrolide resistance – ErmB
  • Macrolide resistance – ErmC
  • Ampicillin – ampC
  • Tetracycline – tetM
  • Carbapenem resistance – VIM
  • Carbapenem resistance – KPC
  • Carbapenem resistance – OXA-23
  • Carbapenem resistance – IMP-16
  • Carbapenem resistance – IMP-7
  • Carbapenem resistance OXA-72
  • Carbapenem resistance OXA-40
  • Carbapenem resistance – OXA-58
  • Carbapenem resistance – OXA-48
  • Carbapenem resistance – NDM
  • Beta-Lactam – blaSHV-5
  • Extended-Spectrum-Betalactamase – SHV
  • Extended-Spectrum-Betalactamase – CTX-M group 1
  • Extended-Spectrum-Betalactamase – CTX-M group 2
  • Extended-Spectrum-Betalactamase – CTX-M group 9
  • Extended-Spectrum-Betalactamase – CTX-M group 8/25

Instructions for Nasopharyngeal Swab Collection

Materials:

  • Sterile Dacron/ Nylon Swab
  • Viral Transport Media Tube (Should contain 1-3mL of sterile viral transport medium)

Patient Preparation

Explain collection procedure to patient prior to collection to reduce anxiety and discomfort.

 Procedure:

  1. Tilt patient’s head back 70 degrees.
  2. Insert swab into nostril. (Swab should reach depth equal to distance from nostrils to outer opening of the ear.) Leave swab in place for several seconds to absorb secretions.
  3. Slowly move swab while rotating it. (Swab both nostrils with same swab.)
  4. Place tip of swab into sterile viral transport media tube and snap/ cut off the applicator stick.

Packing:

  • Label the specimen on the viral transport media tube with two identifiers and ensure cap on tube is tightly sealed. (Do not use a pencil or pen for labeling, as they can rub off or smear. Instead, use a bar code or permanent marker.)
  • Fill out test requisition and ensure that the patient identifiers match the specimen
  • Pack the requisition with the specimen.
  • Include a frozen cold pack with the specimen(s).
  • Pack specimen(s) in accordance with the US Department of Transportation regulations regarding shipment of biological substances.

Shipping:

  • Ship specimens for testing as soon as possible.
  • Store at 2-8 degrees C for no more than three days if shipping will be delayed.

Considerations:

A surgical mask and gloves are recommended at a minimum for all procedures. For some patients and procedures, additional precautions may be indicated, see Standard Precautions here.

Download & Print Instructions
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The Excelsior Guarantee

Excelsior Diagnostics is a specialty medical diagnostic lab that performs all testing exclusively by Polymerase Chain Reaction Molecular Analysis, the most accurate diagnostic medical testing available today.