Diagnosing & Treating Urinary Tract Infection (UTI)

Urinary tract infections (UTIs) are among the most commonly diagnosed conditions among women and account for a disproportionately high percentage of antibiotic prescriptions. In the past, when over 70% of UTIs were caused by E. coli the infections were relatively simple to diagnose and treat. However, the relatively recent emergence of Multi-Drug Resistant Organisms (MDROs) has completely changed the diagnostic and treatment landscapes for UTIs. In fact, without a high degree of accuracy in testing, co-infection and co-morbidities are often missed and the resulting antibiotic interventions can actually do more harm than good as the “wrong” pathogens are targeted and help trigger potentially life-threatening infections caused by Clostridium Difficile, or C. Diff.

How is the test done?

A urine specimen is collected in a sterile specimen collection container and packaged in a prepaid FedEx or UPS overnight envelope. The specimen is overnighted to Excelsior Diagnostics where it is processed by PCR molecular testing and resulted the same day. When the test is positive, the identified bacteria is automatically submitted for Antibiotic Resistance (ABR) Screening, to identify the most effective antibiotic treatment as soon as possible.

How is that better than the standard legacy method?

Simple culture tests have limited specificity and sensitivity which allow unidentified pathogens to go undetected and “hide” and even flourish as antibiotics are administered. The unfortunate result of allowing undetected pathogens to go untreated is a vicious cycle of recurring UTIs. In contrast, Excelsior’s UTI PCR testing identifies 17 pathogens for comprehensive and conclusive results. Unlike legacy culture tests, Excelsior’s testing is not affected by current antibiotic use and eliminates the guesswork by automatically providing an Antibiotic Resistance (ABR) Panel on all positive results. This helps to reduce health costs, avoid hospitalizations, maintain responsible antibiotic stewardship and most importantly, provides immediate and targeted relief.

Acinetobacter baumannii / Citrobacter freundii / Enterobacter aerogenes / Enterobacter cloacae / Enterococcus faecalis / Enterococcus faecium / Escherichia coli / Klebsiella oxytoca / Klebsiella pneumoniae / Morganella morganii / Proteus mirabilis / Proteus vulgaris / Providencia stuartii / Pseudomonas aeruginosa / Staphylococcus saprophyticus / Streptococcus agalactiae (Group B)

Candida albicans 

View the Complete Antibiotic Resistance Panel (ABR)

Antibiotic – Gene
  • Methicillin – mecA
  • Vancomycin – VanA1
  • Vancomycin – VanA2
  • Vancomycin – VanB
  • Quinolone and fluoroquinolone resistance – QnrA
  • Quinolone and fluoroquinolone resistance – QnrB
  • Macrolide resistance – ErmA
  • Macrolide resistance – ErmB
  • Macrolide resistance – ErmC
  • Ampicillin – ampC
  • Tetracycline – tetM
  • Carbapenem resistance – VIM
  • Carbapenem resistance – KPC
  • Carbapenem resistance – OXA-23
  • Carbapenem resistance – IMP-16
  • Carbapenem resistance – IMP-7
  • Carbapenem resistance OXA-72
  • Carbapenem resistance OXA-40
  • Carbapenem resistance – OXA-58
  • Carbapenem resistance – OXA-48
  • Carbapenem resistance – NDM
  • Beta-Lactam – blaSHV-5
  • Extended-Spectrum-Betalactamase – SHV
  • Extended-Spectrum-Betalactamase – CTX-M group 1
  • Extended-Spectrum-Betalactamase – CTX-M group 2
  • Extended-Spectrum-Betalactamase – CTX-M group 9
  • Extended-Spectrum-Betalactamase – CTX-M group 8/25
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The Excelsior Guarantee

Excelsior Diagnostics is a specialty medical diagnostic lab that performs all testing exclusively by Polymerase Chain Reaction Molecular Analysis, the most accurate diagnostic medical testing available today.